Kilpatrick, S. et al. (2014) Plasma cytokine concentrations in dogs with a congenital portosystemic shunt. Veterinary Journal, 200(1), pp. 197-199. (doi: 10.1016/j.tvjl.2014.01.007) (PMID:24518641)
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Abstract
Congenital portosystemic shunts (cPSS) are a well-recognised vascular anomaly in dogs. Recent studies have shown an association between inflammation and hepatic encephalopathy (HE), which is a common clinical syndrome in dogs with a cPSS. Pro-inflammatory cytokines such as interleukin (IL)-6 and tumour necrosis factor (TNF)-α are frequently increased in the plasma of human patients with liver disease and have been implicated in the development of HE. In the current study, plasma concentrations of IL-2, IL-6, IL-8 and TNF-α were measured using a multiplex electrochemiluminescence immunoassay in 36 dogs with a cPSS and compared to 25 healthy dogs. There were no significant differences in plasma IL-2, IL-8 and TNF-α concentrations between the two groups; however, plasma concentrations of IL-6 were significantly higher in dogs with a cPSS compared to healthy dogs (P=0.02).
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Yool, Professor Donald |
| Authors: | Kilpatrick, S., Gow, A. G., Foale, R. D., Tappin, S. W., Carruthers, H., Reed, N., Yool, D. A., Woods, S., Marques, A. I., Jalan, R., and Mellanby, R. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Veterinary Journal |
| Publisher: | Elsevier |
| ISSN: | 1090-0233 |
| ISSN (Online): | 1532-2971 |
| Published Online: | 17 January 2014 |
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