Role of Wnt signalling in advanced prostate cancer

Ahmad, I. and Sansom, O. J. (2018) Role of Wnt signalling in advanced prostate cancer. Journal of Pathology, 245, pp. 3-5. (doi:10.1002/path.5029) (PMID:29314004)

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Abstract

Recent next-generation-sequencing studies demonstrate that multiple pathways are often deregulated in advanced and metastatic prostate cancer (PC). In a recent issue of The Journal of Pathology, an elegant study by Jefferies et al used in vivo modelling to demonstrate how activation of the PI3K, WNT and MAPK pathway converges on mTORC1 signalling to drive aggressive disease. The study also highlights that approaches to target advanced PC require intelligent combination of agents to target single/multiple signalling pathways in combination with androgen receptor (AR) blockade.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ahmad, Dr Imran and Sansom, Professor Owen
Authors: Ahmad, I., and Sansom, O. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Journal of Pathology
Publisher:Wiley
ISSN:0022-3417
ISSN (Online):1096-9896
Published Online:04 January 2018
Copyright Holders:Copyright © 2018 Pathological Society of Great Britain and Ireland
First Published:First published in Journal of Pathology 245:3-5
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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