Cong, W.-j. , Liu, Q., Hu, P., Wang, Y. and Luo, G. (2011) Assay and pharmacokinetic analysis of pirarubicin injection in mouse plasma and heart. Chinese Journal of New Drugs, 20, pp. 451-455.
Full text not currently available from Enlighten.
Abstract
Objective: To establish an assay of pirarubicin in mouse plasma and heart, and to conduct the pharmacokinetic analysis consequently. Methods: Pathogen-free male mice were intravenously (through tail vein) administrated with pirarubicin injection. Plasma and heat samples were collected at various time-points after injection. Extractions were done by adding a mixture of methanol and chloroform (3:1), and the samples were analyzed by HPLC. Results: Extraction recoveries for pirarubicin in the plasma and heart were 85.1% and 81.5%, respectively. Pharmacokinetic analysis showed that pirarubicin could accumulate in the heart. Conclusion: The established method is simple and accurate for plasma as well as heart. Meanwhile, the potential cardiotoxicity of pirarubicin still needs to be concerned.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Cong, Dr Wenjuan |
| Authors: | Cong, W.-j., Liu, Q., Hu, P., Wang, Y., and Luo, G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Chinese Journal of New Drugs |
| Publisher: | Zhongguo Xinyao Zazhi |
| ISSN: | 1003-3734 |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details