Clayton, S. A., Jones, S. W., Kurowska-Stolarska, M. and Clark, A. R. (2018) The role of microRNAs in glucocorticoid action - literature review. Journal of Biological Chemistry, 293(6), pp. 1865-1874. (doi: 10.1074/jbc.R117.000366) (PMID:29301941) (PMCID:PMC5808749)
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Abstract
Glucocorticoids (GCs) are steroids with profound anti-inflammatory and immunomodulatory activities. Synthetic GCs are widely used for managing chronic inflammatory and autoimmune conditions, as immunosuppressants in transplantation, and as antitumor agents in certain hematological cancers. However, prolonged GC exposure can cause adverse effects. A detailed understanding of GCs' mechanisms of action may enable harnessing of their desirable actions while minimizing harmful effects. Here, we review the impact on GC biology of microRNAs, small noncoding RNAs that posttranscriptionally regulate gene expression. Emerging evidence indicates that microRNAs modulate GC production by the adrenal glands and cells' responses to GCs. Furthermore, GCs influence cell proliferation, survival, and function at least in part by regulating microRNA expression. We propose that the beneficial effects of GCs may be enhanced through combination with reagents targeting specific microRNAs.
Item Type: | Articles |
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Keywords: | Apoptosis, epigenetics, glucocorticoid, glucocorticoid receptor, inflammation, microRNA (miRNA). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Kurowska-Stolarska, Professor Mariola |
Authors: | Clayton, S. A., Jones, S. W., Kurowska-Stolarska, M., and Clark, A. R. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Journal of Biological Chemistry |
Publisher: | American Society for Biochemistry and Molecular Biology, Inc. |
ISSN: | 0021-9258 |
ISSN (Online): | 1083-351X |
Published Online: | 04 January 2018 |
Copyright Holders: | Copyright © 2018 The American Society for Biochemistry and Molecular Biology, Inc |
First Published: | First published in Journal of Biological Chemistry 293(6): 1865-1874 |
Publisher Policy: | Reproduced under a Creative Commons License |
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