The role of microRNAs in glucocorticoid action - literature review

Clayton, S. A., Jones, S. W., Kurowska-Stolarska, M. and Clark, A. R. (2018) The role of microRNAs in glucocorticoid action - literature review. Journal of Biological Chemistry, 293(6), pp. 1865-1874. (doi:10.1074/jbc.R117.000366) (PMID:29301941) (PMCID:PMC5808749)

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Abstract

Glucocorticoids (GCs) are steroids with profound anti-inflammatory and immunomodulatory activities. Synthetic GCs are widely used for managing chronic inflammatory and autoimmune conditions, as immunosuppressants in transplantation, and as antitumor agents in certain hematological cancers. However, prolonged GC exposure can cause adverse effects. A detailed understanding of GCs' mechanisms of action may enable harnessing of their desirable actions while minimizing harmful effects. Here, we review the impact on GC biology of microRNAs, small noncoding RNAs that posttranscriptionally regulate gene expression. Emerging evidence indicates that microRNAs modulate GC production by the adrenal glands and cells' responses to GCs. Furthermore, GCs influence cell proliferation, survival, and function at least in part by regulating microRNA expression. We propose that the beneficial effects of GCs may be enhanced through combination with reagents targeting specific microRNAs.

Item Type:Articles
Keywords:Apoptosis, epigenetics, glucocorticoid, glucocorticoid receptor, inflammation, microRNA (miRNA).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kurowska-Stolarska, Dr Mariola
Authors: Clayton, S. A., Jones, S. W., Kurowska-Stolarska, M., and Clark, A. R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Biological Chemistry
Publisher:American Society for Biochemistry and Molecular Biology, Inc.
ISSN:0021-9258
ISSN (Online):1083-351X
Published Online:04 January 2018
Copyright Holders:Copyright © 2018 The American Society for Biochemistry and Molecular Biology, Inc
First Published:First published in Journal of Biological Chemistry 293(6): 1865-1874
Publisher Policy:Reproduced under a Creative Commons License

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