Bhalla, R. J., Trimble, T. A., Leece, E. A. and Vettorato, E. (2018) Comparison of intramuscular butorphanol and buprenorphine combined with dexmedetomidine for sedation in cats. Journal of Feline Medicine and Surgery, 20(4), pp. 325-331. (doi: 10.1177/1098612x17709612) (PMID:28548551)
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Abstract
Objectives: The objective of this study was to compare the sedative effect of butorphanol–dexmedetomidine with buprenorphine–dexmedetomidine following intramuscular (IM) administration in cats. Methods: Using a prospective, randomised, blinded design, 40 client-owned adult cats were assigned to receive IM dexmedetomidine (10 µg/kg) combined with either butorphanol (0.4 mg/kg) (‘BUT’ group) or buprenorphine (20 µg/kg) (‘BUP’ group). Sedation was scored using a previously published multidimensional composite scale before administration (T0) and 5, 10, 15 and 20 mins afterwards (T5, T10, T15 and T20, respectively). Alfaxalone (1.5 mg/kg) was administered IM at T20 if the cat was not deemed adequately sedated to place an intravenous catheter. Adverse events were recorded. Friedman two-way ANOVA analysed sedation scores within groups. Mann–Whitney Rank Sum test compared sedation scores between groups; Fisher’s exact test analysed the frequency of alfaxalone administration and adverse events. P <0.05 was considered statistically significant. Results: Sedation scores between groups were similar at baseline, but at T5, T10, T15 and T20 scores were higher in the BUT group (P <0.01). Within both groups, sedation scores changed over time and the highest sedation scores were reached at T10. Requirement for additional sedation was similar between groups: two cats in the BUT group and five cats in the BUP group. One cat and 11 cats vomited (P = 0.002) in the BUT and BUP groups, respectively. No other adverse events were recorded. Conclusions and relevance: At these doses, IM buprenorphine–dexmedetomidine provides inferior sedation and a higher incidence of vomiting than butorphanol–dexmedetomidine in cats. Butorphanol–dexmedetomidine may be preferred for feline sedation, especially where vomiting is contraindicated.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Trimble, Toby |
Authors: | Bhalla, R. J., Trimble, T. A., Leece, E. A., and Vettorato, E. |
College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | Journal of Feline Medicine and Surgery |
Publisher: | SAGE |
ISSN: | 1098-612X |
ISSN (Online): | 1532-2750 |
Published Online: | 26 May 2017 |
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