Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat

Zepeda Mendoza, M. et al. (2018) Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat. Nature Ecology and Evolution, 2(4), pp. 659-668. (doi:10.1038/s41559-018-0476-8) (PMID:29459707) (PMCID:PMC5868727)

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Abstract

Adaptation to specialized diets often requires modifications at both genomic and microbiome levels. We applied a hologenomic approach to the common vampire bat (Desmodus rotundus), one of the only three obligate blood-feeding (sanguivorous) mammals, to study the evolution of its complex dietary adaptation. Specifically, we assembled its high-quality reference genome (scaffold N50 = 26.9 Mb, contig N50 = 36.6 kb) and gut metagenome, and compared them against those of insectivorous, frugivorous and carnivorous bats. Our analyses showed a particular common vampire bat genomic landscape regarding integrated viral elements, a dietary and phylogenetic influence on gut microbiome taxonomic and functional profiles, and that both genetic elements harbour key traits related to the nutritional (for example, vitamin and lipid shortage) and non-nutritional (for example, nitrogen waste and osmotic homeostasis) challenges of sanguivory. These findings highlight the value of a holistic study of both the host and its microbiota when attempting to decipher adaptations underlying radical dietary lifestyles.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Streicker, Dr Daniel
Authors: Zepeda Mendoza, M., Xiong, Z., Escalera-Zamudio, M., Runge, A. K., Thézé, J., Streicker, D., Frank, H., Loza-Rubio, E., Liu, S., Ryder, O., Samaniego Castruita, J. A., Katzourakis, A., Pacheco, G., Taboada, B., Löber, U., Pybus, O., Li, Y., Rojas-Anaya, E., Bohmann, K., Carmona Baez, A., Arias, C., Liu, S., Greenwood, A., Bertelsen, M., White, N., Bunce, M., Zhang, G., Sicheritz-Ponten, T., and Gilbert, M. T.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Nature Ecology and Evolution
Publisher:Nature Publishing Group
ISSN:2397-334X
ISSN (Online):2397-334X
Published Online:19 February 2018
Copyright Holders:Copyright © 2018 Macmillan Publishers Limited, part of Springer Nature
First Published:First published in Nature Ecology and Evolution 2(4): 659-668
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
634192Managing viral emergence at the interface of bats and livestockDaniel StreickerWellcome Trust (WELLCOTR)102507/Z/13/ZRI BIODIVERSITY ANIMAL HEALTH & COMPMED