The life history of 21 breast cancers

Nik-Zainal, S. et al. (2012) The life history of 21 breast cancers. Cell, 149(5), pp. 994-1007. (doi: 10.1016/j.cell.2012.04.023) (PMID:22608083) (PMCID:PMC3428864)

Abstract

Cancer evolves dynamically as clonal expansions supersede one another driven by shifting selective pressures, mutational processes, and disrupted cancer genes. These processes mark the genome, such that a cancer's life history is encrypted in the somatic mutations present. We developed algorithms to decipher this narrative and applied them to 21 breast cancers. Mutational processes evolve across a cancer's lifespan, with many emerging late but contributing extensive genetic variation. Subclonal diversification is prominent, and most mutations are found in just a fraction of tumor cells. Every tumor has a dominant subclonal lineage, representing more than 50% of tumor cells. Minimal expansion of these subclones occurs until many hundreds to thousands of mutations have accumulated, implying the existence of long-lived, quiescent cell lineages capable of substantial proliferation upon acquisition of enabling genomic changes. Expansion of the dominant subclone to an appreciable mass may therefore represent the final rate-limiting step in a breast cancer's development, triggering diagnosis.

• Item Type: Articles
• Additional Information: The authors ... and Breast Cancer Working Group of the International Cancer Genome Consortium.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cooke, Dr Susie and Martin, Ms Sancha and Marshall, Mr John
• Authors: Nik-Zainal, S., Van Loo, P., Wedge, D. C., Alexandrov, L. B., Greenman, C. D., Lau, K. W., Raine, K., Jones, D., Marshall, J., Ramakrishna, M., Shlien, A., Cooke, S. L., Hinton, J., Menzies, A., Stebbings, L. A., Leroy, C., Jia, M., Rance, R., Mudie, L. J., Gamble, S. J., Stephens, P. J., McLaren, S., Tarpey, P. S., Papaemmanuil, E., Davies, H. R., Varela, I., McBride, D. J., Bignell, G. R., Leung, K., Butler, A. P., Teague, J. W., Martin, S., Jönsson, G., Mariani, O., Boyault, S., Miron, P., Fatima, A., Langerød, A., Aparicio, S. A.J.R., Tutt, A., Sieuwerts, A. M., Borg, Å., Thomas, G., Salomon, A. V., Richardson, A. L., Børresen-Dale, A.-L., Futreal, P. A., Stratton, M. R., and Campbell, P. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Cell
• Publisher: Elsevier (Cell Press)
• ISSN: 0092-8674
• ISSN (Online): 1097-4172
• Published Online: 17 May 2012
• Copyright Holders: Copyright © 2012 Elsevier Inc.
• First Published: First published in Cell 149(5):994-1007
• Publisher Policy: Reproduced under a Creative Commons License