Biocompatible chitosan-functionalized upconverting nanocomposites

Duong, H. V., Chau, T. T. L., Dang, N. T. T., Vanterpool, F., Salmerón-Sánchez, M. , Lizundia, E., Tran, H. T., Nguyen, L. V. and Nguyen, T.-D. (2018) Biocompatible chitosan-functionalized upconverting nanocomposites. ACS Omega, 3(1), pp. 86-95. (doi: 10.1021/acsomega.7b01355)

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Simultaneous integration of photon emission and biocompatibility into nanoparticles is an interesting strategy to develop applications of advanced optical materials. In this work, we present the synthesis of biocompatible optical nanocomposites from the combination of near-infrared luminescent lanthanide nanoparticles and water-soluble chitosan. NaYF4:Yb,Er upconverting nanocrystal guests and water-soluble chitosan hosts are prepared and integrated together into biofunctional optical composites. The control of aqueous dissolution, gelation, assembly, and drying of NaYF4:Yb,Er nanocolloids and chitosan liquids allowed us to design novel optical structures of spongelike aerogels and beadlike microspheres. Well-defined shape and near-infrared response lead upconverting nanocrystals to serve as photon converters to couple with plasmonic gold (Au) nanoparticles. Biocompatible chitosan-stabilized Au/NaYF4:Yb,Er nanocomposites are prepared to show their potential use in biomedicine as we find them exhibiting a half-maximal effective concentration (EC50) of 0.58 mg mL–1 for chitosan-stabilized Au/NaYF4:Yb,Er nanorods versus 0.24 mg mL–1 for chitosan-stabilized NaYF4:Yb,Er after 24 h. As a result of their low cytotoxicity and upconverting response, these novel materials hold promise to be interesting for biomedicine, analytical sensing, and other applications.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Vanterpool, Frankie Artwin and Salmeron-Sanchez, Professor Manuel
Authors: Duong, H. V., Chau, T. T. L., Dang, N. T. T., Vanterpool, F., Salmerón-Sánchez, M., Lizundia, E., Tran, H. T., Nguyen, L. V., and Nguyen, T.-D.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:ACS Omega
Publisher:American Chemical Society
ISSN (Online):2470-1343
Published Online:04 January 2018
Copyright Holders:Copyright © 2018 American Chemical Society
First Published:First published in ACS Omega 3(1): 86-95
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
722061Engineering growth factor microenvironments- a new therapeutic paradigm for regenerative medicineManuel Salmeron-SanchezEngineering and Physical Sciences Research Council (EPSRC)EP/P001114/1ENG - BIOMEDICAL ENGINEERING