Biocatalytic self-assembly cascades

Sahoo, J. K., Pappas, C. G., Sasselli, I. R., Abul-Haija, Y. M. and Ulijn, R. V. (2017) Biocatalytic self-assembly cascades. Angewandte Chemie (International Edition), 56(24), pp. 6828-6832. (doi: 10.1002/anie.201701870) (PMID:28488273)

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Abstract

The properties of supramolecular materials are dictated by both kinetic and thermodynamic aspects, providing opportunities to dynamically regulate morphology and function. Herein, we demonstrate time-dependent regulation of supramolecular self-assembly by connected, kinetically competing enzymatic reactions. Starting from Fmoc-tyrosine phosphate and phenylalanine amide in the presence of an amidase and phosphatase, four distinct self-assembling molecules may be formed which each give rise to distinct morphologies (spheres, fibers, tubes/tapes and sheets). By varying the sequence or ratio in which the enzymes are added to mixtures of precursors, these structures can be (transiently) accessed and interconverted. The approach provides insights into dynamic self-assembly using competing pathways that may aid the design of soft nanostructures with tunable dynamic properties and life times.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Abul-Haija, Yousef
Authors: Sahoo, J. K., Pappas, C. G., Sasselli, I. R., Abul-Haija, Y. M., and Ulijn, R. V.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Angewandte Chemie (International Edition)
Publisher:Wiley
ISSN:1433-7851
ISSN (Online):1521-3773
Published Online:10 May 2017
Copyright Holders:Copyright © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
First Published:First published in Angewandte Chemie (International Edition) 56(24):6828-6832
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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