Pre-conception maternal erythrocyte saturated to unsaturated fatty acid ratio predicts pregnancy after natural cycle frozen embryo transfer

Onyiaodike, C. C. et al. (2018) Pre-conception maternal erythrocyte saturated to unsaturated fatty acid ratio predicts pregnancy after natural cycle frozen embryo transfer. Scientific Reports, 8(1), 1216. (doi:10.1038/s41598-018-19500-0)

[img]
Preview
Text
154638.pdf - Published Version
Available under License Creative Commons Attribution.

1MB

Abstract

The environment for embryo implantation and fetal growth and development is affected by maternal nutritional, metabolic and health status. The aim of this prospective, cohort study was to test whether plasma metabolic and inflammatory biomarkers can predict pregnancy resulting from in vitro fertilisation (IVF). Women with a natural menstrual cycle undergoing frozen embryo transfer (FET) were recruited and fasting baseline blood samples were collected a mean of 3.4 days prior to the luteinising hormone (LH) surge and a non-fasting blood sample was taken on the day of FET. Ongoing pregnancy was defined by positive fetal heartbeat on ultrasound scan at day 45 post LH surge. Thirty-six pregnancies resulted from FET in 143 women. In an overall stepwise multivariable analysis, erythrocyte saturated to unsaturated fatty acid ratio was positively associated with ongoing pregnancy. A similar model incorporating day of FET covariates found that erythrocyte saturated to unsaturated fatty acid ratio, erythrocyte fatty acid average chain length and plasma log-triglycerides predicted ongoing pregnancy. In conclusion, a higher peri-conceptional saturated to unsaturated fatty acid ratio predicted ongoing pregnancy after natural cycle frozen embryo transfer and may reflect a maternal nutritional status that facilitates pregnancy success in this assisted conception scenario.

Item Type:Articles
Additional Information:We acknowledge the generous support of: The Wellbeing of Women/Royal College of Obstetrics and Gynaecology Research Grant (RG/939/07), The Biochemical Society Travel Grant (101008), The Carnegie Trust, The Harold Hyam Wingate Foundation and University of Wollongong Study Leave Assistance Grants.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Nibbs, Professor Robert and Freeman, Dr Dilys and Nelson, Professor Scott and Jordan, Mrs Fiona and Brown, Mrs Elizabeth and Murray, Mrs Heather and Sattar, Professor Naveed
Authors: Onyiaodike, C. C., Murray, H. M., Zhang, R., Meyer, B. J., Jordan, F., Brown, E. A., Nibbs, R. J.B., Lyall, H., Sattar, N., Nelson, S. M., and Freeman, D. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Scientific Reports
Publisher:Nature Publishing Group
ISSN:2045-2322
ISSN (Online):2045-2322
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Scientific Reports 8(1):1216
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record