Neutrophils: homing in on the myeloid mechanisms of metastasis

Leach, J., Morton, J. P. and Sansom, O. J. (2019) Neutrophils: homing in on the myeloid mechanisms of metastasis. Molecular Immunology, 110, pp. 69-76. (doi:10.1016/j.molimm.2017.12.013) (PMID:29269005) (PMCID:PMC6544568)

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Abstract

The metastasis cascade is complex and comprises several stages including local invasion into surrounding tissue, intravasation and survival of tumour cells in the circulation, and extravasation and colonisation of a distant site. It is increasingly clear that these processes are driven not only by signals within the tumour cells, but are also profoundly influenced by stromal cells and signals in the tumour microenvironment. Amongst the many cell types within the tumour microenvironment, immune cells such as lymphocytes, macrophages and neutrophils play a prominent role in tumour development and progression. Neutrophils, however, have only recently emerged as important players, particularly in metastasis. Here we review the current evidence suggesting a multi-faceted role for neutrophils in the metastatic cascade.

Item Type:Articles
Additional Information:This work was supported by Cancer Research UK. JL is funded by an MRC Clinical Research Training Fellowship.
Keywords:Epithelial cancer, metastasis, myeloid cells, neutrophils, tumour microenvironment.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Leach, Dr Joshua and Morton, Dr Jennifer and Sansom, Professor Owen
Authors: Leach, J., Morton, J. P., and Sansom, O. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Molecular Immunology
Publisher:Elsevier
ISSN:0161-5890
ISSN (Online):1872-9142
Published Online:18 December 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Molecular Immunology 110: 69-76
Publisher Policy:Reproduced under a Creative Commons License

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