Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4

Sakamaki, J.-I. and Ryan, K. M. (2017) Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4. Autophagy, 13(11), pp. 2006-2007. (doi:10.1080/15548627.2017.1364822) (PMID:28933601)

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Abstract

Macroautophagy/autophagy is an intracellular recycling system that delivers cytoplasmic organelles and materials to lysosomes for degradation. This process is operated by autophagy-related (ATG) genes and tightly controlled by stress-responsive signaling pathways. Our recent study revealed that autophagy programs are transcriptionally suppressed by the BET family protein BRD4. This repression is alleviated during nutrient deprivation through the AMPK-SIRT1 pathway. Our findings therefore provide new insights into the regulation of autophagy.

Item Type:Articles
Additional Information:Work in the Ryan laboratory is supported by Cancer Research UK (C596/A17196) and Worldwide Cancer Research (16– 1194).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ryan, Professor Kevin
Authors: Sakamaki, J.-I., and Ryan, K. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Autophagy
Publisher:Taylor & Francis
ISSN:1554-8627
ISSN (Online):1554-8635
Published Online:21 September 2017
Copyright Holders:Copyright © 2017 Jun-Ichi Sakamaki and Kevin M. Ryan
First Published:First published in Autophagy 13(11): 2006-2007
Publisher Policy:Reproduced under a Creative Commons License

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