Sakamaki, J.-I. and Ryan, K. M. (2017) Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4. Autophagy, 13(11), pp. 2006-2007. (doi: 10.1080/15548627.2017.1364822) (PMID:28933601) (PMCID:PMC5788487)
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Abstract
Macroautophagy/autophagy is an intracellular recycling system that delivers cytoplasmic organelles and materials to lysosomes for degradation. This process is operated by autophagy-related (ATG) genes and tightly controlled by stress-responsive signaling pathways. Our recent study revealed that autophagy programs are transcriptionally suppressed by the BET family protein BRD4. This repression is alleviated during nutrient deprivation through the AMPK-SIRT1 pathway. Our findings therefore provide new insights into the regulation of autophagy.
Item Type: | Articles |
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Additional Information: | Work in the Ryan laboratory is supported by Cancer Research UK (C596/A17196) and Worldwide Cancer Research (16– 1194). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Ryan, Professor Kevin |
Authors: | Sakamaki, J.-I., and Ryan, K. M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Autophagy |
Publisher: | Taylor & Francis |
ISSN: | 1554-8627 |
ISSN (Online): | 1554-8635 |
Published Online: | 21 September 2017 |
Copyright Holders: | Copyright © 2017 Jun-Ichi Sakamaki and Kevin M. Ryan |
First Published: | First published in Autophagy 13(11): 2006-2007 |
Publisher Policy: | Reproduced under a Creative Commons License |
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