Fish oil-derived n-3 polyunsaturated fatty acids for the prevention and treatment of sarcopenia

Gray, S. R. and Mittendorfer, B. (2018) Fish oil-derived n-3 polyunsaturated fatty acids for the prevention and treatment of sarcopenia. Current Opinion in Clinical Nutrition and Metabolic Care, 21(2), pp. 104-109. (doi: 10.1097/MCO.0000000000000441) (PMID:29232264)

Abstract

Purpose of review: Muscle mass and function decline progressively starting in middle age, which can result in sarcopenia and affect people's mobility and independence later in life. Exercise training and increased protein intake are typically recommended to counteract the age-associated decline in muscle mass and function. However, few people comply with exercise recommendations and the effectiveness of high-protein intake to halt the decline in muscle mass and function has not been proven. This review aims to explore recent developments in the potential for fish-oil derived n-3 polyunsaturated fatty acids (n-3 PUFA) to improve muscle mass and function in older people. Recent findings: The results from several recent studies demonstrate that dietary supplementation with fish oil-derived n-3 PUFA stimulates muscle protein synthesis and improves muscle mass and function in sedentary older adults and augments the resistance exercise training-induced increase in muscle strength in older adults. The exact mechanisms by which fish oil-derived n-3 PUFAs exert their beneficial effects on muscle mass and function remain to be elucidated. Summary: Fish-oil supplementation has antisarcopenic effects and should be considered in the clinical care of older adults.

• Item Type: Articles
• Additional Information: S.R.G. has nothing to declare. Bettina Mittendorfer has received salary support from NIH grants DK 94483, DK 56341 (Nutrition and Obesity Research Center), and UL1 TR000448 (Clinical Translational Science Award), and the Atkins and Pershing Square Foundations during the preparation of this manuscript.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Gray, Professor Stuart
• Authors: Gray, S. R., and Mittendorfer, B.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Current Opinion in Clinical Nutrition and Metabolic Care
• Publisher: Lippincott, Williams & Wilkins
• ISSN: 1363-1950
• ISSN (Online): 1473-6519
• Published Online: 09 December 2017
• Copyright Holders: Copyright © 2017 Wolters Kluwer Health, Inc.
• First Published: First published in Current Opinion in Clinical Nutrition and Metabolic Care 21(2):104-109
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher