Auto-commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells”

de Beauchamp, L., Baquero, P., Kuntz, E. M., Gottlieb, E. and Helgason, G. V. (2018) Auto-commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells”. Molecular and Cellular Oncology, 5(1), e1403532. (doi:10.1080/23723556.2017.1403532) (PMID:28920959)

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Abstract

We have recently uncovered an abnormal increase in mitochondrial oxidative metabolism in therapy-resistant chronic myeloid leukaemia stem cells (LSCs). By simultaneously disrupting mitochondrial respiration and inhibiting BCR-ABL kinase activity using the antibiotic tigecycline and imatinib respectively, we effectively eradicated LSCs and prevented disease relapse in pre-clinical animal models.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kuntz, Elodie Marie and Helgason, Dr Vignir and Gottlieb, Professor Eyal and Baquero, Dr Pablo
Authors: de Beauchamp, L., Baquero, P., Kuntz, E. M., Gottlieb, E., and Helgason, G. V.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Molecular and Cellular Oncology
Publisher:Taylor and Francis
ISSN:2372-3556
ISSN (Online):2372-3548
Published Online:27 November 2017
Copyright Holders:
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<fragment>Copyright © 2018 Taylor & Francis Group, LLC</fragment>
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First Published:First published in Molecular and Cellular Oncology 5(1):e1403532
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
647981CR-UK Centre renewalKaren VousdenCancer Research UK (CRUK)18076RI CANCER SCIENCES
542691Development of a flow cytometry service within the Paul O'Gorman Leukaemia Research CentreAlison MichieThe Kay Kendall Leukaemia Fund (KENDALL)KKL501RI CANCER SCIENCES
608811Autophagy Inhibition Combined with Targeted Therapy for Elimination of CML Stem Cells.Vignir HelgasonThe Kay Kendall Leukaemia Fund (KENDALL)KKL698RI CANCER SCIENCES