Laser differential confocal map microimaging method and device

Beijing Institute of Technology (2015) Laser differential confocal map microimaging method and device. .

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The invention belongs to the technical field of optical microimaging and spectral measurement, and relates to a high-spatial resolution laser differential confocal map microimaging imaging method and device. The core thought of the method is that a differential confocal detection technology is merged with a spectrum detection technology together, and a dichroic beam splitting system (13) is used to carry out nondestructive separation on Reyleigh scattering light and Raman scattering light, wherein the Raman scattering light is treated by spectrum detection, the Reyleigh scattering light is treated by geometric position detection, based on the characteristic that the position of a zero crossing point of a differential confocal curve (43) is accurately corresponding to the focus position, spectrum information of the excitation spot focus position is captured through zero crossing point triggering, the high-spatial resolution spectrum detection is realized, and a method and a device capable of realizing the high-spatial resolution spectrum detection on micro zones of samples are formed. The method and the device have the advantages of being accurate in location, high in spatial resolution, high in sensitivity of spectrum detection and controllable in measurement of focal spot size, and the like, and have a wide application prospect in the fields of biomedicine, evidence collection of tribunal, and the like.

Item Type:Patents
Additional Information:Publication Number: CN103091299A.
Glasgow Author(s) Enlighten ID:Cui, Dr Han
Authors: Zhao, W., Cui, H., Qiu, L., and Wang, Y.
Subjects:Q Science > QC Physics
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
First Published:21 January 2015

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