Improving spatial resolution of confocal Raman microscopy by super-resolution image restoration

Cui, H., Zhao, W., Wang, Y., Fan, Y., Qiu, L. and Zhu, K. (2016) Improving spatial resolution of confocal Raman microscopy by super-resolution image restoration. Optics Express, 24(10), pp. 10767-10776. (doi:10.1364/OE.24.010767)

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Abstract

A new super-resolution image restoration confocal Raman microscopy method (SRIR-RAMAN) is proposed for improving the spatial resolution of confocal Raman microscopy. This method can recover the lost high spatial frequency of the confocal Raman microscopy by using Poisson-MAP super-resolution imaging restoration, thereby improving the spatial resolution of confocal Raman microscopy and realizing its super-resolution imaging. Simulation analyses and experimental results indicate that the spatial resolution of SRIR-RAMAN can be improved by 65% to achieve 200 nm with the same confocal Raman microscopy system. This method can provide a new tool for high spatial resolution micro-probe structure detection in physical chemistry, materials science, biomedical science and other areas.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cui, Dr Han
Authors: Cui, H., Zhao, W., Wang, Y., Fan, Y., Qiu, L., and Zhu, K.
Subjects:Q Science > QC Physics
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Optics Express
Journal Abbr.:OE
Publisher:Optical Society of America
ISSN:1094-4087
ISSN (Online):1094-4087
Published Online:09 May 2016
Copyright Holders:2016 Optical Society of America
First Published:First published in Optics Express 24(10):10767-10776
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.

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