A patient-specific lumped-parameter model of coronary circulation

Duanmu, Z., Yin, M., Fan, X., Yang, X. and Luo, X. (2018) A patient-specific lumped-parameter model of coronary circulation. Scientific Reports, 8, 874. (doi:10.1038/s41598-018-19164-w) (PMID:29343785)

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Abstract

A new lumped-parameter model for coronary hemodynamics is developed. This model is developed for the whole coronary network based on CT scans of a patient-specific geometry including the right coronary tree, which is absent in many previous mathematical models. The model adopts the structured tree model boundary conditions similar to the work of Olufsen et al., thus avoiding the necessity of invasive perfusion measurements. In addition, we also incorporated the effects of the head loss at the two inlets of the large coronary arteries for the first time. The head loss could explain the phenomenon of a sudden increase of the resistance at the inlet of coronary vessel. The estimated blood pressure and flow rate results from the model agree well with the clinical measurements. The computed impedances also match the experimental perfusion measurement. The effects of coronary arterial stenosis are considered and the fractional flow reserve and relative flow in the coronary vessels for a stenotic vessel computed in this model show good agreement with published experimental data. It is believed that the approach could be readily translated to clinical practice to facilitate real time clinical diagnosis.

Item Type:Articles
Additional Information:This work is supported by NSFC (11321062).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Luo, Professor Xiaoyu
Authors: Duanmu, Z., Yin, M., Fan, X., Yang, X., and Luo, X.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:Scientific Reports
Publisher:Nature Publishing Group
ISSN:2045-2322
ISSN (Online):2045-2322
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Scientific Reports 8: 874
Publisher Policy:Reproduced under a Creative Commons License

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