Regulation of hepatic apolipoprotein-B-containing lipoprotein secretion

Pease, R.J. and Leiper, J.M. (1996) Regulation of hepatic apolipoprotein-B-containing lipoprotein secretion. Current Opinion in Lipidology, 7(3), pp. 132-138. (PMID:8818509)

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Abstract

The overall secretion of hepatic lipid as VLDL may be regulated by (i) changing the number of particles secreted as a result of altering apolipoprotein B output and (ii) changing the degree of lipidation of the particles with triacylglycerol so that their diameters vary over a threefold range. Substantial progress has been made in understanding the pathway of triacylglycerol incorporation into VLDL. Less is understood about the processes that commit apolipoprotein B either to secretion or to presecretory degradation, although both regulated translocation and an early lipidation step of the nascent particle with cholesterol or cholesterol ester have been implicated.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Leiper, Professor James
Authors: Pease, R.J., and Leiper, J.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Current Opinion in Lipidology
Publisher:Lippincott, Williams & Wilkins
ISSN:0957-9672
ISSN (Online):1473-6535

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