In vitro activity of Iclaprim against Methicillin-resistant Staphylococcus aureus nonsusceptible to Daptomycin, Linezolid, or Vancomycin: A pilot study

Huang, D. B., Hawser, S., Gemmell, C. and Sahm, D. F. (2017) In vitro activity of Iclaprim against Methicillin-resistant Staphylococcus aureus nonsusceptible to Daptomycin, Linezolid, or Vancomycin: A pilot study. Canadian Journal of Infectious Diseases and Medical Microbiology, 2017, 3948626. (doi: 10.1155/2017/3948626)

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Abstract

Iclaprim is a bacterial dihydrofolate reductase inhibitor in Phase 3 clinical development for the treatment of acute bacterial skin and skin structure infections and hospital-acquired bacterial pneumonia caused by Gram-positive bacteria. Daptomycin, linezolid, and vancomycin are commonly used antibiotics for these indications. With increased selective pressure to these antibiotics, outbreaks of bacterial resistance to these antibiotics have been reported. This in vitro pilot study evaluated the activity of iclaprim against methicillin-resistant Staphylococcus aureus (MRSA) isolates, which were also not susceptible to daptomycin, linezolid, or vancomycin. Iclaprim had an MIC ≤ 1 µg/ml to the majority of MRSA isolates that were nonsusceptible to daptomycin (5 of 7 (71.4%)), linezolid (26 of 26 (100%)), or vancomycin (19 of 28 (66.7%)). In the analysis of time-kill curves, iclaprim demonstrated ≥ 3 log10 reduction in CFU/mL at 4–8 hours for tested strains and isolates nonsusceptible to daptomycin, linezolid, or vancomycin. Together, these data support the use of iclaprim in serious infections caused by MRSA nonsusceptible to daptomycin, linezolid, or vancomycin.

Item Type:Articles
Additional Information:This study was funded by Motif BioSciences.
Keywords:Research Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gemmell, Professor Curtis
Authors: Huang, D. B., Hawser, S., Gemmell, C., and Sahm, D. F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Canadian Journal of Infectious Diseases and Medical Microbiology
Publisher:Hindawi
ISSN:1712-9532
ISSN (Online):1918-1493
Copyright Holders:Copyright © 2017 David B. Huang et al.
First Published:First published in Canadian Journal of Infectious Diseases and Medical Microbiology 2017:3948626
Publisher Policy:Reproduced under a Creative Commons License

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