SPIONs for cell labelling and tracking using MRI: magnetite or maghemite?

Barrow, M., Taylor, A., Fuentes-Caparrós, A. M., Sharkey, J., Daniels, L. M., Mandal, P., Park, B. K., Murray, P., Rosseinsky, M. J. and Adams, D. J. (2018) SPIONs for cell labelling and tracking using MRI: magnetite or maghemite? Biomaterials Science, 6(1), pp. 101-106. (doi:10.1039/c7bm00515f) (PMID:29188240) (PMCID:PMC5793703)

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Abstract

Although there is extensive literature covering the biomedical applications of superparamagnetic iron oxide nanoparticles (SPIONs), the phase of the iron oxide core used is not often taken into account when cell labelling and tracking studies for regenerative medicine are considered. Here, we use a co-precipitation reaction to synthesise particles of both magnetite- (Fe3O4) and maghemite- (γ-Fe2O3) based cores and consider whether the extra synthesis step to make maghemite based particles is advantageous for cell tracking.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Adams, Dave
Authors: Barrow, M., Taylor, A., Fuentes-Caparrós, A. M., Sharkey, J., Daniels, L. M., Mandal, P., Park, B. K., Murray, P., Rosseinsky, M. J., and Adams, D. J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Biomaterials Science
Publisher:Royal Society of Chemistry
ISSN:2047-4830
ISSN (Online):2047-4849
Published Online:23 November 2017
Copyright Holders:Copyright © 2017 The Royal Society of Chemistry
First Published:First published in Biomaterials Science 6(1): 101-106
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
765131UKRMP Safety HubDave AdamsMedical Research Council (MRC)MR/K026739/1SCHOOL OF CHEMISTRY