β2 integrins as regulators of dendritic cell, monocyte, and macrophage function

Schittenhelm, L., Hilkens, C. M. and Morrison, V. L. (2017) β2 integrins as regulators of dendritic cell, monocyte, and macrophage function. Frontiers in Immunology, 8, 1866. (doi:10.3389/fimmu.2017.01866) (PMID:29326724) (PMCID:PMC5742326)

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Abstract

Emerging evidence suggests that the β2 integrin family of adhesion molecules have an important role in suppressing immune activation and inflammation. β2 integrins are important adhesion and signaling molecules that are exclusively expressed on leukocytes. The four β2 integrins (CD11a, CD11b, CD11c, and CD11d paired with the β2 chain CD18) play important roles in regulating three key aspects of immune cell function: recruitment to sites of inflammation; cell–cell contact formation; and downstream effects on cellular signaling. Through these three processes, β2 integrins both contribute to and regulate immune responses. This review explores the pro- and anti-inflammatory effects of β2 integrins in monocytes, macrophages, and dendritic cells and how they influence the outcome of immune responses. We furthermore discuss how imbalances in β2 integrin function can have far-reaching effects on mounting appropriate immune responses, potentially influencing the development and progression of autoimmune and inflammatory diseases. Therapeutic targeting of β2 integrins, therefore, holds enormous potential in exploring treatment options for a variety of inflammatory conditions.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Morrison, Dr Vicky and Schittenhelm, Leonie and Hilkens, Dr Catharien
Authors: Schittenhelm, L., Hilkens, C. M., and Morrison, V. L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Frontiers in Immunology
Publisher:Frontiers Media
ISSN:1664-3224
ISSN (Online):1664-3224
Copyright Holders:Copyright © 2017 Schittenhelm, Hilkens and Morrison
First Published:First published in Frontiers in Immunology 8:1866
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
675353Integrin-mediated regulation of leukocytes in autoimmunity.Vicky MorrisonArthritis Research UK (ARTRESUK)20848RI INFECTION IMMUNITY & INFLAMMATION
602451Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure)Iain McInnesArthritis Research UK (ARTRESUK)MP20298III -IMMUNOLOGY