Towards a neurodynamical understanding of the prodrome in schizophrenia

Mikanmaa, E., Grent-'t-Jong, T. , Hua, L., Recasens, M., Thune, H. and Uhlhaas, P. J. (2019) Towards a neurodynamical understanding of the prodrome in schizophrenia. NeuroImage, 190, pp. 144-153. (doi: 10.1016/j.neuroimage.2017.11.026) (PMID:29175199)

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Abstract

The identification of biomarkers for the early diagnosis of schizophrenia that could inform novel treatment developments is an important objective of current research. This paper will summarize recent work that has investigated changes in oscillatory activity and event-related potentials with Electro/Magnetoencephalography (EEG/MEG) in participants at high-risk for the development of schizophrenia, highlighting disruptions in sensory and cognitive operations prior to the onset of the syndrome. Changes in EEG/MEG-data are consistent with evidence for alterations in Glutamatergic and GABAergic neurotransmission as disclosed by Magnetic Resonance Spectroscopy and brain stimulation, indicating changes in Excitation/Inhibition Parameters prior to the onset of psychosis. Together these data emphasize the importance of research into neuronal dynamics as a crucial approach to establish functional relationships between impairments in neural circuits and emerging psychopathology that together could be fundamental for early intervention and the identification of novel treatments for emerging psychosis.

Item Type:Articles
Keywords:E/I-balance, electrophysiology, neuroscience, oscillations, prodrome, schizophrenia.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Uhlhaas, Professor Peter and Recasens, Dr Marc and Mikanmaa, Miss Emmi and Grent-'T-Jong, Dr Tineke and Hua, Lingling
Authors: Mikanmaa, E., Grent-'t-Jong, T., Hua, L., Recasens, M., Thune, H., and Uhlhaas, P. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
College of Science and Engineering > School of Psychology
Journal Name:NeuroImage
Publisher:Elsevier
ISSN:1053-8119
ISSN (Online):1095-9572
Published Online:22 November 2017
Copyright Holders:Copyright © 2017 Elsevier Inc.
First Published:First published in NeuroImage 190: 144-153
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
640691Using Magnetoencephalography to Investigate Aberrant Neural Synchrony in Prodromal Schizophrenia: A Translational Biomarker ApproachPeter UhlhaasMedical Research Council (MRC)MR/L011689/1RI NEUROSCIENCE & PSYCHOLOGY