Symmetric dimethylarginine (SDMA) is raised in women with polycystic ovary syndrome: A pilot study

Lakhani, K., Kay, A. R., Leiper, J. , Barry, J. A. and Hardiman, P. J. (2011) Symmetric dimethylarginine (SDMA) is raised in women with polycystic ovary syndrome: A pilot study. Journal of Obstetrics and Gynaecology, 31(5), pp. 417-419. (doi: 10.3109/01443615.2011.569779) (PMID:21627426)

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Polycystic ovary syndrome (PCOS) is associated with endothelial dysfunction, which may be caused by elevated levels of asymmetric dimethylarginine (ADMA). ADMA reduces nitric oxide production in diabetes mellitus, hypertension and renal failure. Symmetric dimethylarginine (SDMA) is a stereoisomer produced alongside ADMA, and has recently been described as a risk factor for cardiovascular events. In this cross-sectional study based in a teaching hospital, 16 women with PCOS were recruited alongside 15 healthy controls, and fasting venous blood samples were obtained. Renal function was measured, and ADMA and SDMA were analysed using a high-performance liquid chromatography method. After controlling for BMI, mean ADMA and SDMA levels in women with PCOS were higher than in controls (p = 0.036 and p = 0.030, respectively). Renal function was not different between the two groups (p = 0.152). Women with PCOS have raised levels of SDMA, a molecule implicated in endothelial dysfunction and long-term cardiovascular risk.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Leiper, Professor James
Authors: Lakhani, K., Kay, A. R., Leiper, J., Barry, J. A., and Hardiman, P. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Obstetrics and Gynaecology
Publisher:Taylor and Francis
ISSN (Online):1364-6893
Published Online:31 May 2011

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