Model answers: rational application of murine models in Arthritis research

Benson, R. A. , McInnes, I. B. , Garside, P. and Brewer, J. M. (2018) Model answers: rational application of murine models in Arthritis research. European Journal of Immunology, 48(1), pp. 32-38. (doi: 10.1002/eji.201746938) (PMID:29193037) (PMCID:PMC5814907)

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Advances in targeted immune therapeutics have profoundly improved clinical outcomes for patients with inflammatory arthropathies particularly rheumatoid arthritis. The landscape of disease that is observed and the treatment outcomes desired for the future have also progressed. As such there is an increasing move away from traditional models of end-stage, chronic disease with recognition of the need to consider the earliest phases of pathogenesis as a target for treatment leading to resolution and/or cure. In order to continue the discovery process and enhance our understanding of disease and treatment, we therefore need to continuously revisit the animal models we employ and assess their relevance and utility in the light of contemporary therapeutic goals. In this review, we highlight the areas where we consider new developments in animal models and their application are most required. Thus, we have contextualised the relevant mouse models and their use within the current concepts of human inflammatory arthritis pathogenesis and highlight areas of need.

Item Type:Articles
Keywords:Immunology, immunology and allergy.
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain and Benson, Dr Robert and Brewer, Professor James and Garside, Professor Paul
Authors: Benson, R. A., McInnes, I. B., Garside, P., and Brewer, J. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:European Journal of Immunology
ISSN (Online):1521-4141
Published Online:14 December 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in European Journal of Immunology 48(1):32-38
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
568541Defining the Role of Cell Migration in the Initiation and Regulation of Pathogenesis in Inflammatory ArthritisPaul GarsideArthritis Research UK (ARTRESUK)19788III -IMMUNOLOGY