Roberts, R. G., Freeman, T. C., Kendall, E., Vetrie, D. L.P. , Dixon, A. K., Shaw-Smith, C., Bone, Q. and Bobrow, M. (1996) Characterization of DRP2, a novel human dystrophin homologue. Nature Genetics, 13(2), pp. 223-226. (doi: 10.1038/ng0696-223) (PMID:8640231)
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Abstract
The currently recognised dystrophin protein family comprises the archetype, dystrophin, its close relative, utrophin or dystrophin-related protein (DRP), and a distantly related protein known as the 87K tyrosine kinase substrate. During the course of a phylogenetic study of sequences encoding the characteristic C-terminal domains of dystrophin-related proteins, we identified an unexpected novel class of vertebrate dystrophin-related sequences. We term this class dystrophin-related protein 2 (DRP2), and suggest that utrophin/DRP be renamed DRP1 to simplify future nomenclature. DRP2 is a relatively small protein, encoded in man by a 45 kb gene localized to Xq22. It is expressed principally in the brain and spinal cord, and is similar in overall structure to the Dp116 dystrophin isoform. The discovery of a novel relative of dystrophin substantially broadens the scope for study of this interesting group of proteins and their associated glycoprotein complexes.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Vetrie, Professor David |
| Authors: | Roberts, R. G., Freeman, T. C., Kendall, E., Vetrie, D. L.P., Dixon, A. K., Shaw-Smith, C., Bone, Q., and Bobrow, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Nature Genetics |
| Publisher: | Nature Publishing Group |
| ISSN: | 1061-4036 |
| ISSN (Online): | 1546-1718 |
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