The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins

Jin, H., Kendall, E., Freeman, T. C., Roberts, R. G. and Vetrie, D. L.P. (1999) The human family of deafness/dystonia peptide (DDP) related mitochondrial import proteins. Genomics, 61(3), pp. 259-267. (doi: 10.1006/geno.1999.5966) (PMID:10552927)

Full text not currently available from Enlighten.

Abstract

The gene responsible for the human genetic neurodegenerative disorder DFN-1/MTS encodes a small protein known as deafness/dystonia peptide (DDP). It bears a strong resemblance to a recently characterized set of zinc-binding yeast proteins (Tim8p, Tim9p, Tim10p, Tim12p, and Tim13p) that are implicated in the import of a class of transmembrane carrier proteins from the cytoplasm to the mitochondrial inner membrane. We describe here the human complement of DDP/Tim-like proteins and establish the likely orthologous relationships between sequences from human, yeast, and other organisms. We also describe the expression patterns and chromosomal locations of their genes, which are candidate loci for autosomal recessive neurodegenerative disorders.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vetrie, Professor David
Authors: Jin, H., Kendall, E., Freeman, T. C., Roberts, R. G., and Vetrie, D. L.P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Genomics
Publisher:Elsevier
ISSN:0888-7543
ISSN (Online):1089-8646

University Staff: Request a correction | Enlighten Editors: Update this record