Molecular biology of amitraz resistance in cattle ticks of the genus Rhipicephalus

Jonsson, N. N. , Klafke, G., Corley, S. W., Tidwell, J., Berry, C. M. and Koh-Tan, H.H. C. (2018) Molecular biology of amitraz resistance in cattle ticks of the genus Rhipicephalus. Frontiers in Bioscience, 23(2), pp. 796-810. (doi:10.2741/4617) (PMID:28930573)

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Abstract

Amitraz is an important product for the control of cattle ticks around the world. In comparison with other products for the control of ticks, it is quite affordable and it has a rapid knock-down effect. It binds with and activates adrenergic neuro-receptors of animals and it inhibits the action of monoamine oxidases (MAO). Resistance to amitraz has been documented in Rhipicephalus microplus, R. decoloratus and R. appendiculatus. Four mechanisms of resistance have been proposed, each of which is supported by evidence but none of which has been definitively confirmed as the cause of resistance in the field. The proposed mechanisms include genetic target site insensitivity in two G protein-coupled receptors, the beta-adrenergic octopamine receptor (BAOR) and the octopamine/tyramine receptor (OCT/Tyr), increased expression or activity of monoamine oxidases and increased expression or activity of the ATP binding cassette transporter.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jonsson, Professor Nicholas and Koh-Tan, Dr Han Hui and Berry, Mrs Christina
Authors: Jonsson, N. N., Klafke, G., Corley, S. W., Tidwell, J., Berry, C. M., and Koh-Tan, H.H. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Frontiers in Bioscience
Publisher:Frontiers in Bioscience
ISSN:1093-9946
ISSN (Online):1093-4715
Copyright Holders:Copyright © 2017 Frontiers in Bioscience
First Published:First published in Frontiers in Bioscience 23(2): 796-810
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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