Jonsson, N. N. , Klafke, G., Corley, S. W., Tidwell, J., Berry, C. M. and Koh-Tan, H.H. C. (2018) Molecular biology of amitraz resistance in cattle ticks of the genus Rhipicephalus. Frontiers in Bioscience: Landmark, 23(2), pp. 796-810. (doi: 10.2741/4617) (PMID:28930573)
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Abstract
Amitraz is an important product for the control of cattle ticks around the world. In comparison with other products for the control of ticks, it is quite affordable and it has a rapid knock-down effect. It binds with and activates adrenergic neuro-receptors of animals and it inhibits the action of monoamine oxidases (MAO). Resistance to amitraz has been documented in Rhipicephalus microplus, R. decoloratus and R. appendiculatus. Four mechanisms of resistance have been proposed, each of which is supported by evidence but none of which has been definitively confirmed as the cause of resistance in the field. The proposed mechanisms include genetic target site insensitivity in two G protein-coupled receptors, the beta-adrenergic octopamine receptor (BAOR) and the octopamine/tyramine receptor (OCT/Tyr), increased expression or activity of monoamine oxidases and increased expression or activity of the ATP binding cassette transporter.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Jonsson, Professor Nicholas and Koh-Tan, Dr Caline and Berry, Mrs Christina |
| Authors: | Jonsson, N. N., Klafke, G., Corley, S. W., Tidwell, J., Berry, C. M., and Koh-Tan, H.H. C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Frontiers in Bioscience: Landmark |
| Publisher: | Frontiers in Bioscience |
| ISSN: | 1093-9946 |
| ISSN (Online): | 1093-4715 |
| Copyright Holders: | Copyright © 2017 Frontiers in Bioscience |
| First Published: | First published in Frontiers in Bioscience: Landmark 23(2): 796-810 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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