HIV type 1 diversity in northeastern Romania in 200-2001 based on phylogenic analysis of pol sequences from patient failing antiretroviral therapy

Apetrei, C., Descamps, D., Collin, G., Robertson, D. L. , Pandrea, I., Groza, P., Prisecariu, L., Teodorescu, I., Luca, V. and Brun-Vézinet, F. (2003) HIV type 1 diversity in northeastern Romania in 200-2001 based on phylogenic analysis of pol sequences from patient failing antiretroviral therapy. AIDS Research and Human Retroviruses, 19(12), pp. 1155-1161. (doi:10.1089/088922203771881266) (PMID:14714572)

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Abstract

Protease and the first half of reverse transcriptase from 71 Romanian patients failing highly active antiretroviral therapy (HAART) have been sequenced and phylogenetically analyzed. These analyses show that 70 patients were infected with subtype F1 and one with subtype C. The pattern of drug resistance mutations in subtype F1-infected patients failing HAART is similar to that described for subtype B strains. These results show that the diversity pattern of HIV type 1 infection in Romania has remained steady over a decade, with subtype F1 remaining the predominant viral form. The circulation of subtype F1 in Romania has the potential to be a source of this HIV-1 subtype in Europe.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Robertson, Professor David
Authors: Apetrei, C., Descamps, D., Collin, G., Robertson, D. L., Pandrea, I., Groza, P., Prisecariu, L., Teodorescu, I., Luca, V., and Brun-Vézinet, F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:AIDS Research and Human Retroviruses
Publisher:Mary Ann Liebert
ISSN:0889-2229
ISSN (Online):1931-8405

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