Amoutzias, G. D., Robertson, D. L. , Oliver, S. G. and Bornberg-Bauer, E. (2004) Convergent evolution of gene networks by single-gene duplications in higher eukaryotes. EMBO Reports, 5(3), pp. 274-279. (doi: 10.1038/sj.embor.7400096) (PMID:14968135) (PMCID:PMC1299007)
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Abstract
By combining phylogenetic, proteomic and structural information, we have elucidated the evolutionary driving forces for the gene-regulatory interaction networks of basic helix-loop-helix transcription factors. We infer that recurrent events of single-gene duplication and domain rearrangement repeatedly gave rise to distinct networks with almost identical hub-based topologies, and multiple activators and repressors. We thus provide the first empirical evidence for scale-free protein networks emerging through single-gene duplications, the dominant importance of molecular modularity in the bottom-up construction of complex biological entities, and the convergent evolution of networks.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Robertson, Professor David |
| Authors: | Amoutzias, G. D., Robertson, D. L., Oliver, S. G., and Bornberg-Bauer, E. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | EMBO Reports |
| Publisher: | EMBO Press |
| ISSN: | 1469-221X |
| ISSN (Online): | 1469-3178 |
| Published Online: | 13 February 2004 |
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