Huxley-Jones, J., Pinney, J. W., Archer, J., Robertson, D. L. and Boot-Handford, R. P. (2009) Back to basics--how the evolution of the extracellular matrix underpinned vertebrate evolution. International Journal of Experimental Pathology, 90(2), pp. 95-100. (doi: 10.1111/j.1365-2613.2008.00637.x) (PMID:19335547)
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Abstract
The extracellular matrix (ECM) is a complex substrate that is involved in and influences a spectrum of behaviours such as growth and differentiation and is the basis for the structure of tissues. Although a characteristic of all metazoans, the ECM has elaborated into a variety of tissues unique to vertebrates, such as bone, tendon and cartilage. Here we review recent advances in our understanding of the molecular evolution of the ECM. Furthermore, we demonstrate that ECM genes represent a pivotal family of proteins the evolution of which appears to have played an important role in the evolution of vertebrates.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Robertson, Professor David |
| Authors: | Huxley-Jones, J., Pinney, J. W., Archer, J., Robertson, D. L., and Boot-Handford, R. P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | International Journal of Experimental Pathology |
| Publisher: | Wiley |
| ISSN: | 0959-9673 |
| ISSN (Online): | 1365-2613 |
| Published Online: | 18 March 2009 |
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