Back to basics--how the evolution of the extracellular matrix underpinned vertebrate evolution

Huxley-Jones, J., Pinney, J. W., Archer, J., Robertson, D. L. and Boot-Handford, R. P. (2009) Back to basics--how the evolution of the extracellular matrix underpinned vertebrate evolution. International Journal of Experimental Pathology, 90(2), pp. 95-100. (doi:10.1111/j.1365-2613.2008.00637.x) (PMID:19335547)

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Abstract

The extracellular matrix (ECM) is a complex substrate that is involved in and influences a spectrum of behaviours such as growth and differentiation and is the basis for the structure of tissues. Although a characteristic of all metazoans, the ECM has elaborated into a variety of tissues unique to vertebrates, such as bone, tendon and cartilage. Here we review recent advances in our understanding of the molecular evolution of the ECM. Furthermore, we demonstrate that ECM genes represent a pivotal family of proteins the evolution of which appears to have played an important role in the evolution of vertebrates.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Robertson, Professor David
Authors: Huxley-Jones, J., Pinney, J. W., Archer, J., Robertson, D. L., and Boot-Handford, R. P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:International Journal of Experimental Pathology
Publisher:Wiley
ISSN:0959-9673
ISSN (Online):1365-2613
Published Online:18 March 2009

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