The pain interactome: connecting pain-specific protein interactions

Jamieson, D. G., Moss, A., Kennedy, M., Jones, S., Nenadic, G., Robertson, D. L. and Sidders, B. (2014) The pain interactome: connecting pain-specific protein interactions. Pain, 155(11), pp. 2243-2252. (doi: 10.1016/j.pain.2014.06.020) (PMID:24978826) (PMCID:PMC4247380)

Abstract

Understanding the molecular mechanisms associated with disease is a central goal of modern medical research. As such, many thousands of experiments have been published that detail individual molecular events that contribute to a disease. Here we use a semi-automated text mining approach to accurately and exhaustively curate the primary literature for chronic pain states. In so doing, we create a comprehensive network of 1,002 contextualized protein-protein interactions (PPIs) specifically associated with pain. The PPIs form a highly interconnected and coherent structure, and the resulting network provides an alternative to those derived from connecting genes associated with pain using interactions that have not been shown to occur in a painful state. We exploit the contextual data associated with our interactions to analyse subnetworks specific to inflammatory and neuropathic pain, and to various anatomical regions. Here, we identify potential targets for further study and several drug-repurposing opportunities. Finally, the network provides a framework for the interpretation of new data within the field of pain.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Robertson, Professor David
• Authors: Jamieson, D. G., Moss, A., Kennedy, M., Jones, S., Nenadic, G., Robertson, D. L., and Sidders, B.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
• Journal Name: Pain
• Publisher: Elsevier
• ISSN: 0304-3959
• ISSN (Online): 1872-6623
• Copyright Holders: Copyright © 2014 The Authors
• First Published: First published in Pain 155: 2243-2252
• Publisher Policy: Reproduced under a Creative Commons License