Dietary antioxidants, food deprivation and growth affect differently oxidative status of blood and brain in juvenile European seabass (Dicentrarchus labrax)

Costantini, D., Angeletti, D., Strinati, C., Trisolino, P., Carlini, A., Nascetti, G. and Carere, C. (2018) Dietary antioxidants, food deprivation and growth affect differently oxidative status of blood and brain in juvenile European seabass (Dicentrarchus labrax). Comparative Biochemistry and Physiology. Part A: Molecular and Integrative Physiology, 216, pp. 1-7. (doi: 10.1016/j.cbpa.2017.10.032) (PMID:29113780)

Abstract

Compensatory growth may increase molecular oxidative damage, which may be mitigated through the intake of dietary antioxidants. However, dietary antioxidants may also reduce concentration of antioxidant enzymes, which have a key role in regulating the oxidative status. Here we investigated whether feeding on a diet rich in antioxidants (vitamin E) enables juvenile European seabass (Dicentrarchus labrax) to catch up after a period of food deprivation with negligible effects on the oxidative stress to blood and brain as compared to fish feeding on a normal diet (i.e., not enriched in antioxidants). The results show that a higher intake in antioxidants favoured compensatory growth, but this came at a cost in terms of increased oxidative damage. Increased intake of antioxidants also resulted in changes in the activity of enzymatic antioxidant defences and increased protein oxidative damage in both brain and blood. In addition, food deprivation caused increased protein oxidative damage in brain. Our findings show that the beneficial effects of dietary antioxidants on growth may be offset by hidden detrimental effects and that different early life events affect different components of oxidative status of a given tissue.

• Item Type: Articles
• Keywords: Antioxidants, aquaculture, early life, fish, food restriction, oxidative stress.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Costantini, Dr David
• Authors: Costantini, D., Angeletti, D., Strinati, C., Trisolino, P., Carlini, A., Nascetti, G., and Carere, C.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Comparative Biochemistry and Physiology. Part A: Molecular and Integrative Physiology
• Publisher: Elsevier
• ISSN: 1095-6433
• ISSN (Online): 1531-4332
• Published Online: 04 November 2017
• Copyright Holders: Copyright © 2017 Elsevier Inc.
• First Published: First published in Comparative Biochemistry and Physiology. Part A: Molecular and Integrative Physiology 216: 1-7
• Publisher Policy: Reproduced in accordance with the publisher copyright policy