Barrier-tissue macrophages: functional adaptation to environmental challenges

Mowat, A. M., Scott, C. L. and Bain, C. C. (2017) Barrier-tissue macrophages: functional adaptation to environmental challenges. Nature Medicine, 23(11), pp. 1258-1270. (doi: 10.1038/nm.4430) (PMID:29117177)

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Abstract

Macrophages are found throughout the body, where they have crucial roles in tissue development, homeostasis and remodeling, as well as being sentinels of the innate immune system that can contribute to protective immunity and inflammation. Barrier tissues, such as the intestine, lung, skin and liver, are exposed constantly to the outside world, which places special demands on resident cell populations such as macrophages. Here we review the mounting evidence that although macrophages in different barrier tissues may be derived from distinct progenitors, their highly specific properties are shaped by the local environment, which allows them to adapt precisely to the needs of their anatomical niche. We discuss the properties of macrophages in steady-state barrier tissues, outline the factors that shape their differentiation and behavior and describe how macrophages change during protective immunity and inflammation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Bain, Mr Calum and Mowat, Professor Allan
Authors: Mowat, A. M., Scott, C. L., and Bain, C. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Nature Medicine
Publisher:Nature Publishing Group
ISSN:1078-8956
ISSN (Online):1546-170X
Published Online:07 November 2017
Copyright Holders:Copyright © 2017 Nature America, Inc., part of Springer Nature
First Published:First published in Nature Medicine 23(11): 1258-1270
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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