Oncology modeling for fun and profit! Key steps for busy analysts in health technology assessment

Beca, J., Husereau, D., Chan, K. K.W., Hawkins, N. and Hoch, J. S. (2018) Oncology modeling for fun and profit! Key steps for busy analysts in health technology assessment. PharmacoEconomics, 36(1), pp. 7-15. (doi:10.1007/s40273-017-0583-4) (PMID:29110141)

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Abstract

In evaluating new oncology medicines, two common modeling approaches are state transition (e.g., Markov and semi-Markov) and partitioned survival. Partitioned survival models have become more prominent in oncology health technology assessment processes in recent years. Our experience in conducting and evaluating models for economic evaluation has highlighted many important and practical pitfalls. As there is little guidance available on best practices for those who wish to conduct them, we provide guidance in the form of 'Key steps for busy analysts,' who may have very little time and require highly favorable results. Our guidance highlights the continued need for rigorous conduct and transparent reporting of economic evaluations regardless of the modeling approach taken, and the importance of modeling that better reflects reality, which includes better approaches to considering plausibility, estimating relative treatment effects, dealing with post-progression effects, and appropriate characterization of the uncertainty from modeling itself.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hawkins, Professor Neil
Authors: Beca, J., Husereau, D., Chan, K. K.W., Hawkins, N., and Hoch, J. S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Health Economics and Health Technology Assessment
Journal Name:PharmacoEconomics
Publisher:Springer
ISSN:1170-7690
ISSN (Online):1179-2027
Published Online:06 November 2017
Copyright Holders:Copyright © 2017 Springer International Publishing AG
First Published:First published in PharmacoEconomics 36(1): 7-15
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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