Oncology modeling for fun and profit! Key steps for busy analysts in health technology assessment

Beca, J., Husereau, D., Chan, K. K.W., Hawkins, N. and Hoch, J. S. (2018) Oncology modeling for fun and profit! Key steps for busy analysts in health technology assessment. PharmacoEconomics, 36(1), pp. 7-15. (doi: 10.1007/s40273-017-0583-4) (PMID:29110141)

Abstract

In evaluating new oncology medicines, two common modeling approaches are state transition (e.g., Markov and semi-Markov) and partitioned survival. Partitioned survival models have become more prominent in oncology health technology assessment processes in recent years. Our experience in conducting and evaluating models for economic evaluation has highlighted many important and practical pitfalls. As there is little guidance available on best practices for those who wish to conduct them, we provide guidance in the form of 'Key steps for busy analysts,' who may have very little time and require highly favorable results. Our guidance highlights the continued need for rigorous conduct and transparent reporting of economic evaluations regardless of the modeling approach taken, and the importance of modeling that better reflects reality, which includes better approaches to considering plausibility, estimating relative treatment effects, dealing with post-progression effects, and appropriate characterization of the uncertainty from modeling itself.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Hawkins, Professor Neil
• Authors: Beca, J., Husereau, D., Chan, K. K.W., Hawkins, N., and Hoch, J. S.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Health Economics and Health Technology Assessment
• Journal Name: PharmacoEconomics
• Publisher: Springer
• ISSN: 1170-7690
• ISSN (Online): 1179-2027
• Published Online: 06 November 2017
• Copyright Holders: Copyright © 2017 Springer International Publishing AG
• First Published: First published in PharmacoEconomics 36(1): 7-15
• Publisher Policy: Reproduced in accordance with the publisher copyright policy