SNARE phosphorylation: a control mechanism for insulin-stimulated glucose transport and other regulated exocytic events

Laidlaw, K. M.E., Livingstone, R. , Al-Tobi, M. , Bryant, N. J. and Gould, G. W. (2017) SNARE phosphorylation: a control mechanism for insulin-stimulated glucose transport and other regulated exocytic events. Biochemical Society Transactions, 45(6), pp. 1271-1277. (doi:10.1042/BST20170202) (PMID:29101310)

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Abstract

Trafficking within eukaryotic cells is a complex and highly regulated process; events such as recycling of plasma membrane receptors, formation of multivesicular bodies, regulated release of hormones and delivery of proteins to membranes all require directionality and specificity. The underpinning processes, including cargo selection, membrane fusion, trafficking flow and timing, are controlled by a variety of molecular mechanisms and engage multiple families of lipids and proteins. Here, we will focus on control of trafficking processes via the action of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family of proteins, in particular their regulation by phosphorylation. We will describe how these proteins are controlled in a range of regulated trafficking events, with particular emphasis on the insulin-stimulated delivery of glucose transporters to the surface of adipose and muscle cells. Here, we focus on a few examples of SNARE phosphorylation which exemplify distinct ways in which SNARE machinery phosphorylation may regulate membrane fusion.

Item Type:Articles
Additional Information:Work in G.W.G. and N.J.B. groups is supported by grants from Diabetes UK (G.W.G. and N.J.B.) and the Novo Nordisk Research Foundation (G.W.G.). M.A.-T. thanks the Omani Government for a scholarship. K.M.E.L. is supported by a PhD studentship from Diabetes UK.
Keywords:SNARE, glucose transport, insulin, phosphorylation.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gould, Professor Gwyn and Livingstone, Dr Rachel and AL TOBI, Mohammed Nasser Rashid and LAIDLAW, Kamilla and Bryant, Dr Nia
Authors: Laidlaw, K. M.E., Livingstone, R., Al-Tobi, M., Bryant, N. J., and Gould, G. W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Biochemical Society Transactions
Publisher:Portland Press
ISSN:0300-5127
ISSN (Online):1470-8752
Published Online:03 November 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Biochemical Society Transactions 2017
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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