Duration of breastfeeding and risk of SIDS: an individual participant data meta-analysis

Thompson, J. M.D., Tanabe, K., Moon, R. Y., Mitchell, E. A., McGarvey, C., Tappin, D. , Blair, P. S. and Hauck, F. R. (2017) Duration of breastfeeding and risk of SIDS: an individual participant data meta-analysis. Pediatrics, 140(5), e20171324. (doi:10.1542/peds.2017-1324) (PMID:29084835)

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Abstract

CONTEXT: Sudden infant death syndrome (SIDS) is a leading cause of postneonatal infant mortality. Our previous meta-analyses showed that any breastfeeding is protective against SIDS with exclusive breastfeeding conferring a stronger effect.The duration of breastfeeding required to confer a protective effect is unknown. OBJECTIVE: To assess the associations between breastfeeding duration and SIDS. DATA SOURCES: Individual-level data from 8 case-control studies. STUDY SELECTION: Case-control SIDS studies with breastfeeding data. DATA EXTRACTION: Breastfeeding variables, demographic factors, and other potential confounders were identified. Individual-study and pooled analyses were performed. RESULTS: A total of 2267 SIDS cases and 6837 control infants were included. In multivariable pooled analysis, breastfeeding for <2 months was not protective (adjusted odds ratio [aOR]: 0.91, 95% confidence interval [CI]: 0.68–1.22). Any breastfeeding ≥2 months was protective, with greater protection seen with increased duration (2–4 months: aOR: 0.60, 95% CI: 0.44–0.82; 4–6 months: aOR: 0.40, 95% CI: 0.26–0.63; and >6 months: aOR: 0.36, 95% CI: 0.22–0.61). Although exclusive breastfeeding for <2 months was not protective (aOR: 0.82, 95% CI: 0.59–1.14), longer periods were protective (2–4 months: aOR: 0.61, 95% CI: 0.42–0.87; 4–6 months: aOR: 0.46, 95% CI: 0.29–0.74). LIMITATIONS: The variables collected in each study varied slightly, limiting our ability to include all studies in the analysis and control for all confounders. CONCLUSIONS: Breastfeeding duration of at least 2 months was associated with half the risk of SIDS. Breastfeeding does not need to be exclusive to confer this protection.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Tappin, Professor David
Authors: Thompson, J. M.D., Tanabe, K., Moon, R. Y., Mitchell, E. A., McGarvey, C., Tappin, D., Blair, P. S., and Hauck, F. R.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Pediatrics
Publisher:American Academy of Pediatrics
ISSN:0031-4005
ISSN (Online):1098-4275
Copyright Holders:Copyright © 2017 American Academy of Pediatrics
First Published:First published in Pediatrics 140(5):e20171324
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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