An update on diabetes related skeletal fragility

Abdalrahaman, N., Chen, S. C., Wang, J. R. and Ahmed, S. F. (2015) An update on diabetes related skeletal fragility. Expert Review of Endocrinology and Metabolism, 10(2), pp. 193-210. (doi: 10.1586/17446651.2015.984687)

Full text not currently available from Enlighten.


There are several mechanisms by which diabetes could affect bone mass and strength. These mechanisms include insulin deficiency; hyperglycemia; the accumulation of advanced glycation end products that may influence collagen characteristics; marrow adiposity and bone inflammation. Furthermore, associated diabetic complications and treatment with thaizolidinediones may also increase risk of fracturing. The following article provides its readers with an update on the latest information pertaining to diabetes related bone skeletal fragility. In the authors’ opinion, future studies are needed in order to clarify the impact of different aspects of diabetes metabolism, glycemic control, and specific treatments for diabetes on bone. Given that dual energy x-ray absorptiometry is a poor predictor of bone morbidity in this group of patients, there is a need to explore novel approaches for assessing bone quality. It is important that we develop a better understanding of how diabetes affects bone in order to improve our ability to protect bone health and prevent fractures in the growing population of adults with diabetes.

Item Type:Articles
Glasgow Author(s) Enlighten ID:ABDALRAHAMAN, Naiemh and Chen, Dr Ching and Ahmed, Professor Syed Faisal
Authors: Abdalrahaman, N., Chen, S. C., Wang, J. R., and Ahmed, S. F.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Expert Review of Endocrinology and Metabolism
Publisher:Taylor and Francis
ISSN (Online):1744-8417
Published Online:02 January 2015

University Staff: Request a correction | Enlighten Editors: Update this record