The role of malignant tissue on the thermal distribution of cancerous breast

Ramírez-Torres, A. , Rodríguez-Ramos, R., Sabina, F. J., García-Reimbert, C., Penta, R. , Merodio, J., Guinovart-Díaz, R., Bravo-Castillero, J., Conci, A. and Preziosi, L. (2017) The role of malignant tissue on the thermal distribution of cancerous breast. Journal of Theoretical Biology, 426, pp. 152-161. (doi: 10.1016/j.jtbi.2017.05.031) (PMID:28552555)

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Abstract

The present work focuses on the integration of analytical and numerical strategies to investigate the thermal distribution of cancerous breasts. Coupled stationary bioheat transfer equations are considered for the glandular and heterogeneous tumor regions, which are characterized by different thermophysical properties. The cross-section of the cancerous breast is identified by a homogeneous glandular tissue that surrounds the heterogeneous tumor tissue, which is assumed to be a two-phase periodic composite with non-overlapping circular inclusions and a square lattice distribution, wherein the constituents exhibit isotropic thermal conductivity behavior. Asymptotic periodic homogenization method is used to find the effective properties in the heterogeneous region. The tissue effective thermal conductivities are computed analytically and then used in the homogenized model, which is solved numerically. Results are compared with appropriate experimental data reported in the literature. In particular, the tissue scale temperature profile agrees with experimental observations. Moreover, as a novelty result we find that the tumor volume fraction in the heterogeneous zone influences the breast surface temperature.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Penta, Dr Raimondo and Ramirez Torres, Dr Ariel
Authors: Ramírez-Torres, A., Rodríguez-Ramos, R., Sabina, F. J., García-Reimbert, C., Penta, R., Merodio, J., Guinovart-Díaz, R., Bravo-Castillero, J., Conci, A., and Preziosi, L.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:Journal of Theoretical Biology
Publisher:Elsevier
ISSN:0022-5193
ISSN (Online):1095-8541
Published Online:26 May 2017
Copyright Holders:Copyright © 2017 Elsevier, Ltd.
First Published:First published in Journal of Theoretical Biology 426:152-161
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.

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