Low oxygen affinity variant haemoglobin in an elderly woman presenting with low oxygen saturation

Igbineweka, N. E., Horne, G. A. , Jackson, M. B. and Chevassut, T. J. (2015) Low oxygen affinity variant haemoglobin in an elderly woman presenting with low oxygen saturation. Acute Medicine, 14(2), pp. 72-6. (PMID:26305085)

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Abstract

An asymptomatic 81-year-old woman was referred by her general practitioner regarding a pulse-oximetry oxygen saturation (SpO2) of 74%. An arterial blood gas analysis (ABG) on air showed PaO2 12.9 kPa, oxygen saturation 80%, with normal pH, PaCO2, methaemoglobin and carboxyhaemoglobin levels. After a normal chest x-ray, tinzaparin was administered empirically for possible occult pulmonary embolus. This diagnosis was subsequently excluded with an unremarkable computed tomography pulmonary angiogram (CTPA). She was further investigated as an out patient. DNA globin-gene analysis identified a variant haemoglobin revealed to be haemoglobin Saint Mande (HbSM). Following reassurance regarding the benign nature of her condition, she has remained well.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Horne, Dr Gillian
Authors: Igbineweka, N. E., Horne, G. A., Jackson, M. B., and Chevassut, T. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Acute Medicine
Publisher:Rila
ISSN:1747-4884
ISSN (Online):1747-4892

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