The gastric acid pocket (or coat) and its attenuation in helicobacter pylori-infected subjects

McColl, K. E.L. (2018) The gastric acid pocket (or coat) and its attenuation in helicobacter pylori-infected subjects. Journal of Clinical Gastroenterology, 52(1), pp. 1-5. (doi: 10.1097/MCG.0000000000000939) (PMID:29076882)

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Abstract

In 2001, it was observed that the cardia region of the lumen of the stomach remained highly acidic after a meal and escaped the buffering effect of the food. This phenomenon was termed the acid pocket and is thought to explain why reflux symptoms occur after meals despite the buffering effect of food. This review describes the discovery of the acid pocket and our progress in understanding the intragastric physiology producing it, its exaggeration in hiatus hernia and role in reflux disease. The recent discovery that the acid pocket is attenuated in the Helicobacter pylori-infected population and the significance of this to the negative association between H. pylori and reflux disease and its complications is also addressed. Finally, the role of the acid pocket in providing protection from potentially pathogenic ingested microorganisms is discussed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McColl, Professor Kenneth
Authors: McColl, K. E.L.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Journal of Clinical Gastroenterology
Publisher:Lippincott, Williams and Wilkins
ISSN:0192-0790
ISSN (Online):1539-2031
Published Online:25 October 2017

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