Webster, S., O'Rourke, K. M., Fletcher, C., Pimlott, S. L. , Sutherland, A. and Lee, A.-L. (2018) Rapid iododeboronation with and without gold catalysis: application to radiolabelling of arenes. Chemistry: A European Journal, 24(4), pp. 937-943. (doi: 10.1002/chem.201704534) (PMID:29105856) (PMCID:PMC5814724)
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Abstract
Radiopharmaceuticals incorporating radioactive iodine in combination with SPECT imaging play a key role in nuclear medicine, with applications in drug development and disease diagnosis. Despite this importance, there are relatively few general methods for incorporating radioiodine into small molecules. Here we describe a rapid, air- and moisture-stable ipso-iododeboronation procedure using NIS, in the non-toxic and green solvent dimethyl carbonate. The fast reaction and mild conditions of the gold-catalysed method led to the development of a highly efficient process for radiolabelling of arenes, which constitutes the first example of an application of homogenous gold catalysis to selective radiosynthesis. This has been exemplified with an effective synthesis of radiolabelled meta-[125I]iodobenzylguanidine, a radiopharmaceutical used for the imaging and therapy of human norepinephrine transporter-expressing tumours.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Pimlott, Dr Sally and O'Rourke, Kerry and Sutherland, Professor Andrew |
| Authors: | Webster, S., O'Rourke, K. M., Fletcher, C., Pimlott, S. L., Sutherland, A., and Lee, A.-L. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing College of Science and Engineering > School of Chemistry |
| Journal Name: | Chemistry: A European Journal |
| Publisher: | Wiley |
| ISSN: | 0947-6539 |
| ISSN (Online): | 1521-3765 |
| Published Online: | 06 November 2017 |
| Copyright Holders: | Copyright © 2018 The Authors |
| First Published: | First published in Chemistry: A European Journal 24(4): 937-943 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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