Predictive feedback to V1 dynamically updates with sensory input

Edwards, G., Vetter, P., McGruer, F., Petro, L. S. and Muckli, L. (2017) Predictive feedback to V1 dynamically updates with sensory input. Scientific Reports, 7, 16538. (doi:10.1038/s41598-017-16093-y) (PMID:29184060) (PMCID:PMC5705713)

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Abstract

Predictive coding theories propose that the brain creates internal models of the environment to predict upcoming sensory input. Hierarchical predictive coding models of vision postulate that higher visual areas generate predictions of sensory inputs and feed them back to early visual cortex. In V1, sensory inputs that do not match the predictions lead to amplified brain activation, but does this amplification process dynamically update to new retinotopic locations with eye-movements? We investigated the effect of eye-movements in predictive feedback using functional brain imaging and eye-tracking whilst presenting an apparent motion illusion. Apparent motion induces an internal model of motion, during which sensory predictions of the illusory motion feed back to V1. We observed attenuated BOLD responses to predicted stimuli at the new post-saccadic location in V1. Therefore, pre-saccadic predictions update their retinotopic location in time for post-saccadic input, validating dynamic predictive coding theories in V1.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McGruer, Dr Fiona and Petro, Dr Lucy and Vetter, Dr Petra and Edwards, Miss Grace and Muckli, Professor Lars
Authors: Edwards, G., Vetter, P., McGruer, F., Petro, L. S., and Muckli, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Scientific Reports
Publisher:Nature Publishing Group
ISSN:2045-2322
ISSN (Online):2045-2322
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Scientific Reports 7:16538
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
474481Brain processes predicting forthcoming perception - cortical feedback and visual predictionsLars MuckliBiotechnology and Biological Sciences Research Council (BBSRC)BB/G005044/1INP - CENTRE FOR COGNITIVE NEUROIMAGING
593891Brain reading of contextual feedback and predictions - BrainReadFBPredCodeLars MuckliEuropean Research Council (ERC)ERC-2012-Stg-311751INP - CENTRE FOR COGNITIVE NEUROIMAGING