Animal models to explore the effects of glucocorticoids on skeletal growth and structure

Wood, C. L., Soucek, O., Wong, J. , Zaman, F., Farquharson, C., Savendahl, L. and Ahmed, S. F. (2018) Animal models to explore the effects of glucocorticoids on skeletal growth and structure. Journal of Endocrinology, 236, R69-R91. (doi: 10.1530/JOE-17-0361) (PMID:29051192)

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Abstract

Glucocorticoids (GCs) are effective for the treatment of many chronic conditions but their use is associated with frequent and wide-ranging adverse effects including osteoporosis and growth retardation. The mechanisms that underlie the undesirable effects of GCs on skeletal development are unclear and there is no proven effective treatment to combat them. An in-vivo model that investigates the development and progression of GC-induced changes in bone is, therefore, important and a well characterized pre-clinical model is vital for the evaluation of new interventions. Currently, there is no established animal model to investigate GC effects on skeletal development and there are pros and cons to consider with the different protocols used to induce osteoporosis and growth retardation. This review will summarize the literature and highlight the models and techniques employed in experimental studies to date.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ahmed, Professor Syed Faisal and Wong, Dr Jarod
Authors: Wood, C. L., Soucek, O., Wong, J., Zaman, F., Farquharson, C., Savendahl, L., and Ahmed, S. F.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Journal of Endocrinology
Publisher:BioScientifica Ltd.
ISSN:0022-0795
ISSN (Online):1479-6805
Published Online:19 October 2017
Copyright Holders:Copyright © 2017 Society for Endocrinology
First Published:First published in Journal of Endocrinology 236:R69-R91
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
676381Secondary Osteoporosis & Its Therapy in Duchenne Muscular Dystrophy - ScOT-DMDSyed Faisal AhmedChief Scientist office (CSO)CAF/DMD/14/01SCHOOL OF MEDICINE, DENTISTRY & NURSING