Culex quinquefasciatus mosquitoes do not support replication of Zika virus

Lourenço-de-Oliveira, R., Marques, J. T., Sreenu, V. B. , Nten, C. A., Guimarães Rocha Aguiarr, E. R., Varjak, M. , Kohl, A. and Failloux, A.-B. (2018) Culex quinquefasciatus mosquitoes do not support replication of Zika virus. Journal of General Virology, 99, pp. 258-264. (doi:10.1099/jgv.0.000949) (PMID:29076805) (PMCID:PMC5882084)

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Abstract

The rapid spread of Zika virus (ZIKV) in the Americas raised many questions about the role of Culex quinquefasciatus mosquitoes in transmission, in addition to the key role played by the vector Aedes aegypti. Here we analysed the competence of Cx. quinquefasciatus (with or without Wolbachia endosymbionts) for a ZIKV isolate. We also examined the induction of RNA interference pathways after viral challenge and the production of small virus-derived RNAs. We did not observe any infection nor such small virus-derived RNAs, regardless of the presence or absence of Wolbachia. Thus, Cx. quinquefasciatus does not support ZIKV replication and Wolbachia is not involved in producing this phenotype. In short, these mosquitoes are very unlikely to play a role in transmission of ZIKV.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vattipally, Dr Sreenu and Varjak, Dr Margus and Kohl, Professor Alain
Authors: Lourenço-de-Oliveira, R., Marques, J. T., Sreenu, V. B., Nten, C. A., Guimarães Rocha Aguiarr, E. R., Varjak, M., Kohl, A., and Failloux, A.-B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of General Virology
Publisher:Microbiology Society
ISSN:0022-1317
ISSN (Online):1465-2099
Published Online:27 October 2017
Copyright Holders:Copyright © 2017 The Authors
First Published:First published in Journal of General Virology 99:258-264
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
737371ZikallianceAlain KohlEuropean Commission (EC)734548MVLS III - CENTRE FOR VIRUS RESEARCH
698111MAPPAlain KohlEuropean Commission (EC)661232MVLS III - CENTRE FOR VIRUS RESEARCH
656551Arbovirus interactions with arthropod hostsAlain KohlMedical Research Council (MRC)MC_UU_12014/8MVLS III - CENTRE FOR VIRUS RESEARCH

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