Ellgaard, L., Sevier, C. S. and Bulleid, N. (2018) How are proteins reduced in the endoplasmic reticulum? Trends in Biochemical Sciences, 43(1), pp. 32-43. (doi: 10.1016/j.tibs.2017.10.006) (PMID:29153511) (PMCID:PMC5751730)
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Abstract
The reversal of thiol oxidation in proteins within the endoplasmic reticulum (ER) is crucial for protein folding, degradation, chaperone function, and the ER stress response. Our understanding of this process is generally poor but progress has been made. Enzymes performing the initial reduction of client proteins, as well as the ultimate electron donor in the pathway, have been identified. Most recently, a role for the cytosol in ER protein reduction has been revealed. Nevertheless, how reducing equivalents are transferred from the cytosol to the ER lumen remains an open question. We review here why proteins are reduced in the ER, discuss recent data on catalysis of steps in the pathway, and consider the implications for redox homeostasis within the early secretory pathway.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Bulleid, Professor Neil |
| Authors: | Ellgaard, L., Sevier, C. S., and Bulleid, N. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Trends in Biochemical Sciences |
| Publisher: | Elsevier |
| ISSN: | 0968-0004 |
| ISSN (Online): | 1362-4326 |
| Published Online: | 15 November 2017 |
| Copyright Holders: | Copyright © 2017 The Authors |
| First Published: | First published in Trends in Biochemical Sciences 43(1):32-43 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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