Ubiquitin signalling in DNA replication and repair

Ulrich, H. D. and Walden, H. (2010) Ubiquitin signalling in DNA replication and repair. Nature Reviews Molecular Cell Biology, 11(7), pp. 479-489. (doi: 10.1038/nrm2921) (PMID:20551964)

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Abstract

Post-translational modification by ubiquitin is best known for its role in targeting its substrates for regulated degradation. However, non-proteolytic functions of the ubiquitin system, often involving either monoubiquitylation or polyubiquitylation through Lys63-linked chains, have emerged in various cell signalling pathways. These two forms of the ubiquitin signal contribute to three different pathways related to the maintenance of genome integrity that are responsible for the processing of DNA double-strand breaks, the repair of interstrand cross links and the bypass of lesions during DNA replication.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Walden, Professor Helen
Authors: Ulrich, H. D., and Walden, H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Nature Reviews Molecular Cell Biology
ISSN:1471-0072
ISSN (Online):1471-0080
Published Online:16 June 2010

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