Plasma cholesteryl ester fatty acids do not mediate the association of ethnicity with type 2 diabetes: results from the HELIUS study

Muilwijk, M., Celis-Morales, C. , Nicolaou, M., Snijder, M. B., Gill, J. M.R. and van Valkengoed, I. G.M. (2018) Plasma cholesteryl ester fatty acids do not mediate the association of ethnicity with type 2 diabetes: results from the HELIUS study. Molecular Nutrition and Food Research, 62(2), 1700528. (doi:10.1002/mnfr.201700528) (PMID:28981995)

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Abstract

Scope: Ethnic minority groups have a higher risk of type 2 diabetes (T2D) than the host population. Our aim was to identify whether plasma cholesteryl ester fatty acids (CEFA) mediate the ethnic differences in type 2 diabetes. Methods and results: We included 202 Dutch, 206 South-Asian Surinamese, 205 African Surinamese, 215 Turkish and 213 Moroccan origin participants of the HELIUS study (Amsterdam, the Netherlands). Logistic regression was used to determine the associations between plasma CEFA and T2D. Mediation analysis was used to identify whether CEFA contributed to the association between ethnicity and T2D. We adjusted for ethnicity, age, sex, smoking, physical activity and BMI. Associations between plasma CEFA and T2D were similar across all ethnic groups. Although differences in plasma CEFA across ethnic groups were observed, CEFA did not mediate the differences in T2D prevalence between ethnic groups. Conclusion: Although ethnic differences in plasma CEFA were found and CEFA were associated with T2D, CEFA did not contribute to the difference in T2D prevalence between ethnic groups. If confirmed, this implies that maintenance of the more beneficial CEFA profiles in the non-Dutch ethnic groups may be encouraged to prevent an even higher prevalence of T2D in these groups.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Celis, Dr Carlos and Gill, Professor Jason
Authors: Muilwijk, M., Celis-Morales, C., Nicolaou, M., Snijder, M. B., Gill, J. M.R., and van Valkengoed, I. G.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Molecular Nutrition and Food Research
Publisher:Wiley
ISSN:1613-4125
ISSN (Online):1613-4133
Published Online:05 October 2017
Copyright Holders:Copyright © 2017 Wiley-VCH Verlag GmbH & Co.
First Published:First published in Molecular Nutrition and Food Research 62(2):1700528
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
704241InPreSDJason GillEuropean Commission (EC)664609RI CARDIOVASCULAR & MEDICAL SCIENCES