Onchocerca volvulus: the road from basic biology to a vaccine

Lustigman, S., Makepeace, B. L., Klei, T. R., Babayan, S. A. , Hotez, P., Abraham, D. and Bottazzi, M. E. (2018) Onchocerca volvulus: the road from basic biology to a vaccine. Trends in Parasitology, 34(1), pp. 64-79. (doi:10.1016/j.pt.2017.08.011) (PMID:28958602)

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Abstract

Human onchocerciasis - commonly known as river blindness - is one of the most devastating yet neglected tropical diseases, leaving many millions in sub-Saharan Africa blind and/or with chronic disabilities. Attempts to eliminate onchocerciasis, primarily through the mass drug administration of ivermectin, remains challenging and has been heightened by the recent news that drug-resistant parasites are developing in some populations after years of drug treatment. Needed, and needed now, in the fight to eliminate onchocerciasis are new tools, such as preventive and therapeutic vaccines. This review summarizes the progress made to advance the onchocerciasis vaccine from the research laboratory into the clinic.

Item Type:Articles
Keywords:Onchocerca volvulus, elimination, vaccine, vaccine candidates.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Babayan, Dr Simon
Authors: Lustigman, S., Makepeace, B. L., Klei, T. R., Babayan, S. A., Hotez, P., Abraham, D., and Bottazzi, M. E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Trends in Parasitology
Publisher:Elsevier
ISSN:1471-4922
ISSN (Online):1471-5007
Published Online:22 September 2017

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