Karympalis, V., Kalopita, K., Zarros, A. and Carageorgiou, H. (2004) Regulation of gene expression via triple helical formations. Biochemistry (Moscow), 69(8), pp. 855-860. (doi: 10.1023/B:BIRY.0000040216.18119.d5) (PMID:15377264)
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Abstract
Triplex-forming oligonucleotides (TFOs) are a challenging and very promising subject in modern biochemistry and molecular genetics. Over the last decade, several studies have stated that TFOs: a) can bind to DNA in a sequence-specific manner; b) can provoke DNA repair and recombination in mammalian cells, and c) can be a very effective biological tool in embryonic and oncogenic research on gene expression pathways. Herein we review the basic modes in which TFOs exist, their gene-regulation properties, as well as the obstacles that should be overcome before they become useful in clinical practice (chemotherapy and/or gene therapy).
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Zarros, Dr Apostolos |
| Authors: | Karympalis, V., Kalopita, K., Zarros, A., and Carageorgiou, H. |
| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH345 Biochemistry Q Science > QH Natural history > QH426 Genetics |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Biochemistry (Moscow) |
| Publisher: | Springer Verlag |
| ISSN: | 0006-2979 |
| ISSN (Online): | 1608-3040 |
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