Katsouni, E., Sakkas, P., Zarros, A. , Skandali, N. and Liapi, C. (2009) The involvement of substance P in the induction of aggressive behavior. Peptides, 30(8), pp. 1586-1591. (doi: 10.1016/j.peptides.2009.05.001) (PMID:19442694)
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Abstract
Aggression is a complex social behavior that involves a similarly complex neurochemical background. The involvement of substance P (SP) and its potent tachykinin receptor (NK1) in the induction of both defensive rage and predatory attack appears to be a consistent finding. However, an overall understanding of the nature of the SP involvement in the induction of aggressive behavior has not yet been fully achieved. The aim of this review is to summarize and present the current knowledge with regards to the role of SP in the induction of aggressive behavior and to synopsize: (a) its biochemical profile, and (b) the exact anatomical circuits through which it mediates all types of aggressive behavior. Future studies should seriously consider the potential use of this knowledge in their quest for the treatment of mood and anxiety disorders.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Zarros, Dr Apostolos |
| Authors: | Katsouni, E., Sakkas, P., Zarros, A., Skandali, N., and Liapi, C. |
| Subjects: | R Medicine > RB Pathology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RM Therapeutics. Pharmacology |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Peptides |
| Publisher: | Elsevier |
| ISSN: | 0196-9781 |
| ISSN (Online): | 1873-5169 |
| Published Online: | 13 May 2009 |
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